Publications by authors named "T Lacaze-Masmonteil"

Article Synopsis
  • Adaptive designs (ADs) in clinical trials make the testing process more flexible and can save time and money.
  • Many people in the medical field don’t fully understand how these designs work, so a review has been done to explain their use in research.
  • The study looked at a lot of research reports from 2010 to 2020 and found that most ADs were used in trials for adults, especially for cancer treatments, with a smaller number for children.
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Background: Despite global efforts to improve paediatric clinical trials, significant delays continue in paediatric drug approvals. Collaboration between research networks is needed to address these delays. This paper is a first step to promote interoperability between paediatric networks from different jurisdictions by comparing drivers for, and content of, metrics about clinical trial conduct.

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Article Synopsis
  • Innovative therapeutic approaches are necessary to support children and young adults with rare and chronic conditions, emphasizing better access to clinical research and off-label treatments.
  • Health Canada introduced the Single Patient Study (SPS) to give access to non-marketed drugs for patients with serious conditions when traditional clinical trials are unavailable.
  • The report discusses the SPS's impact on the Canadian healthcare landscape, addressing both the opportunities it presents and the challenges faced by stakeholders like regulators, pharmaceutical companies, and patient advocates.
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Background: Apnoea of prematurity (AOP) is one of the most common diagnoses among preterm infants. AOP often leads to hypoxemia and bradycardia which are associated with an increased risk of death or disability. In addition to caffeine therapy and non-invasive respiratory support, doxapram might be used to reduce hypoxemic episodes and the need for invasive mechanical ventilation in preterm infants, thereby possibly improving their long-term outcome.

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