Publications by authors named "T L ten Hagen"
Article Synopsis
- RSV is a significant cause of severe respiratory issues in adults, with a study involving 111 hospitalized patients revealing a 12% mortality rate and high rates of co-morbidities and bacterial pneumonia.
- The research included a comparison between immunocompromised and immunocompetent patients, finding that complications were similar in both groups.
- The study emphasizes the need for proactive investigations and treatment strategies for adults diagnosed with RSV due to the high incidence of severe symptoms and bacterial infections.
Introduction: The COVID-19 pandemic overwhelmed health systems, resulting in a surge in excess deaths. This study clustered countries based on excess mortality to understand their response to the pandemic and the influence of various factors on excess mortality within each cluster.
Materials And Methods: This ecological study is part of the COVID-19 MORtality (C-MOR) Consortium.
In the canonical genetic code, many amino acids are assigned more than one codon. Work by us and others has shown that the choice of these synonymous codon is not random, and carries regulatory and functional consequences. Existing protein foundation models ignore this context-dependent role of coding sequence in shaping the protein landscape of the cell.
View Article and Find Full Text PDFBackground: Extracellular vesicles (EVs) are cell-secreted particles conceived as natural vehicles for intercellular communication. The capacity to entrap heterogeneous molecular cargoes and target specific cell populations through EV functionalization promises advancements in biomedical applications. However, the efficiency of the obtained EVs, the contribution of cell-exposed receptors to EV interactions, and the predictability of functional cargo release with potential sharing of high molecular weight recombinant mRNAs are crucial for advancing heterologous EVs in targeted therapy applications.
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- Leishmania is a protozoan parasite that causes serious diseases such as cutaneous and visceral leishmaniasis, heavily impacting impoverished communities with limited medical resources.
- Current treatments are toxic and not very effective, prompting the need for research into the parasite's metabolism to find new drug targets.
- The study focused on the unique enzyme LiAcs1 from Leishmania infantum, which has both acetyl-CoA synthetase and acetoacetyl-CoA synthetase activities, revealing it as a promising target for developing selective inhibitors to disrupt the parasite's critical metabolic pathways.