Maximizing the translational potential of neurophysiology in amyotrophic lateral sclerosis: a study on compound muscle action potentials.

Mouse models of amyotrophic lateral sclerosis (ALS) enable testing of novel therapeutic interventions. However, treatments that have extended survival in mice have often failed to translate into human benefit in clinical trials. Compound muscle action potentials (CMAPs) are a simple neurophysiological test that measures the summation of muscle fiber depolarization in response to maximal stimulation of the innervating nerve.

Understanding the pathophysiology of colonization as a guide for future treatment for chronic leg ulcers.

Chronic leg wounds represent a major burden of disease worldwide, costing health care systems billions of dollars each year. Aside from the financial implications, they also impose a significant physical and psychosocial burden on the patient, their relatives and/or carers, and the community. Whilst measures such as maintenance of wound hygiene, debridement, dressings and compression are the current standard of care, complete healing is not always achievable and ulcer recurrence is common.

Development and Characterization of Spray-Dried Combined Levofloxacin-Ambroxol Dry Powder Inhaler Formulation.

This study explores the development and characterization of spray-dried composite microparticles consisting of levofloxacin (LVX, a broad-spectrum antibiotic), and ambroxol (AMB, a mucolytic agent that has antibacterial and antibiofilm properties), for the intended application of the drug against lower respiratory tract infections (LRTIs). A range of LVX to AMB mass ratios (1:1, 1:0.5, and 1:0.

Notes on (Convolvulaceae) from Ecuador.

Fieldwork, examination of herbarium specimens and photographic images, supported by molecular sequencing have resulted in the re-interpretation of a number of species of L. found in Ecuador and the recognition of four new species. Standl.

The research behind a taxonomic monograph: a case study from (Convolvulaceae).

Systematic monographs are an important tool for understanding biodiversity. However, while papers that outline systematic methods for biogeography, phylogenetics and diversification are commonplace, papers that cover methods for monographic and taxonomic research are rare. In this paper, we describe how we conducted a monographic study of , drawing attention to the resources we made use of and the practical steps we took, with a particular focus on how we integrated results from molecular and morphological analyses.