Publications by authors named "T L Vollmer"
Background And Objectives: Early treatment of multiple sclerosis (MS) reduces disease activity and the risk of long-term disease progression. Effectiveness of ocrelizumab is established in relapsing MS (RMS); however, data in early RMS are lacking. We evaluated the 4-year effectiveness and safety of ocrelizumab as a first-line therapy in treatment-naive patients with recently diagnosed relapsing-remitting MS (RRMS).
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- - Patients with multiple sclerosis (PwMS) face a higher risk of infections, especially those treated with ocrelizumab (OCR), as shown in a study involving 6,155 patients over a median period of 3.7 years.
- - Serious infections (SIs) were reported at an incidence rate of 1.50 per 100 patient years for relapsing MS and 3.70 for progressive MS, with lower respiratory, urinary, abdominal, gastrointestinal, and skin infections being the most common.
- - Significant risk factors for SIs included comorbidities, recent relapses, and higher disability scores, particularly in patients with progressive MS where a high EDSS score indicated a fourfold increase in
Reinforcers frequently chosen may not offer the same nutritional value as fruits and vegetables. Prior researchers have explored preferences and the effectiveness of salty and sweet foods compared to fruits and vegetables, but the criteria for demonstrating effectiveness have often been arbitrary rather than academic. In addition, it remains unclear how the integration of these potentially nutritious reinforcers might affect learning or hinder learning efficiency.
View Article and Find Full Text PDFEvaluation of a Novel Independent Group Contingency in an Alternative School.
Behav Anal Pract
September 2024
Article Synopsis
- The study tested a new group contingency system aimed at helping teachers in alternative education overcome common challenges, such as high effort needed, disruption from feedback, and student resistance.
- To tackle these issues, the researchers simplified the process, eliminated feedback for rule violations, created a strategy to handle sabotage, and kept reinforcement criteria secret from students.
- The results showed significant decreases in classroom disruption across four different alternative middle and high school classes.
Regulatory T cells (T cells) hold promise for sustainable therapy of immune disorders. Recent advancements in chimeric antigen receptor development and genome editing aim to enhance the specificity and function of T cells. However, impurities and functional instability pose challenges for the development of safe gene-edited T cell products.
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