Identification of novel, non-invasive, non-cognitive based markers of Alzheimer's disease (AD) and related dementias are a global priority. Growing evidence suggests that Alzheimer's pathology manifests in sensory association areas well before appearing in neural regions involved in higher-order cognitive functions, such as memory. Previous investigations have not comprehensively examined the interplay of sensory, cognitive, and motor dysfunction with relation to AD progression.
View Article and Find Full Text PDFFront Microbiol
August 2022
CC22-MRSA is a major MRSA lineage that is widely reported globally. To characterize CC22-MRSA for trends in antibiotic resistance and emergence of variants, a total of 636 CC22 isolates identified by DNA microarray in 2016 ( = 195), 2017 ( = 227) and 2018 ( = 214) were investigated further using staphylococcal protein A () typing and multilocus sequence typing. The isolates belonged to 109 types dominated by t223 ( = 160), t032 ( = 60), t852 ( = 59), t005 ( = 56) and t309 ( = 30) and 10 sequence types (STs) dominated by ST22 (85.
View Article and Find Full Text PDF[This corrects the article DOI: 10.1016/j.jceh.
View Article and Find Full Text PDFFollowing a surge in the prevalence of chloramphenicol-resistant methicillin-resistant (MRSA) in Kuwait hospitals, this study investigated the genotypes and antibiotic resistance of the chloramphenicol-resistant isolates to ascertain whether they represented new or a resurgence of sporadic endemic clones. Fifty-four chloramphenicol-resistant MRSA isolates obtained in 2014-2015 were investigated. Antibiotic resistance was tested by disk diffusion and MIC determination.
View Article and Find Full Text PDFObjective: The aim of this study was to investigate the genetic determinants of fusidic acid (FA) resistance in MRSA isolated from patients in Kuwait hospitals.
Methods: The minimum inhibitory concentration (MIC) of FA was tested with E-test strips. Genetic determinants of FA were determined by PCR and DNA microarray.