Publications by authors named "T L Stewart"
Time is a central dimension against which perception, action, and cognition play out. From anticipating when future events will happen to recalling how long ago previous events occurred, humans and animals are exquisitely sensitive to temporal structure. Empirical evidence seems to suggest that estimating time prospectively (i.
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- This study examines a new healthcare model in New Zealand that combines a low-carbohydrate diet and health coaching to help manage prediabetes and Type 2 diabetes.
- Participants reported health benefits like weight loss and increased energy, while also facing challenges such as resistance from some healthcare providers and misconceptions about low-carb diets.
- The model shows promise for improving patient outcomes and reducing the workload on healthcare professionals, though further education and awareness are needed for wider adoption.
Supraphysiological androgen (SPA) treatment can paradoxically restrict growth of castration-resistant prostate cancer with high androgen receptor (AR) activity, which is the basis for use of Bipolar Androgen Therapy (BAT) for patients with this disease. While androgens are widely appreciated to enhance anabolic metabolism, how SPA-mediated metabolic changes alter prostate cancer progression and therapy response is unknown. Here, we report that SPA markedly increased intracellular and secreted polyamines in prostate cancer models.
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- The study assesses real-world outcomes and failure patterns in patients with muscle-invasive bladder cancer (MIBC) who underwent trimodality therapy (TMT) between 2000 and 2018, utilizing data from the Veterans Affairs database.
- Results indicate that out of 347 patients treated with TMT, 44% had no recurrence, while 37% experienced metastatic recurrence (MR) and 34% had local recurrence (LR), highlighting significant rates of recurrence within the patient population.
- The findings suggest that TMT is generally effective in treating MIBC, but the high recurrence rates, particularly with lymph node positive disease and pre-treatment hydronephrosis, stress the importance of ongoing patient monitoring and the exploration of better treatment strategies