Publications by authors named "T L Seum"
Lung cancer screening by low-dose computed tomography reduces lung cancer mortality, but reliable risk-based selection of participants is crucial to maximize benefits and minimize harms. Multiple risk models have been developed for this purpose, and their discrimination and calibration performance is commonly evaluated based on large-scale cohort studies. Using a recent comparative evaluation of 10 risk models as an example, we illustrate the merits, limitations and pitfalls of such evaluations.
View Article and Find Full Text PDFRisk-Adapted Starting Ages of Colorectal Cancer Screening for People With Diabetes or Metabolic Syndrome.
Aliment Pharmacol Ther
December 2024
Background: Individuals with diabetes and metabolic syndrome have an increased risk of colorectal cancer (CRC), suggesting earlier screening than the average-risk population may be warranted.
Aims: To derive risk-adapted starting ages of CRC screening for people with diabetes or metabolic syndrome.
Methods: We determined 5-year cumulative risks of CRC at individual ages between 30 and 50 across Europe (overall and individually for Germany, France, the UK and Italy) and North America (the United States and Canada) based on the GLOBOCAN 2022 database.
Article Synopsis
- * The analysis included 26 studies with variability in sample sizes and methods; 13 studies focused on single metabolites (mostly lipids), while 11 developed panels of metabolites, with two doing both types of assessments.
- * Metabolite panels, particularly lipid-based ones, show potential for identifying CRC risks, boasting AUC values between 0.69 and 1.0, but their clinical application is hindered by the need for standardization and further validation.*