Publications by authors named "T L Powley"
Introduction: No clear guidelines exist for unfractionated heparin (UFH) monitoring in adult patients on veno-arterial extracorporeal life support (VA-ECLS) for refractory cardiogenic shock. In this study, we sought to compare outcomes between anti-factor Xa (FXa) and activated partial thromboplastin time (aPTT) strategies for UFH monitoring during VA-ECLS.
Methods: This is a single-center, retrospective review of VA-ECLS patients who received UFH in the cardiothoracic intensive care unit between July 2019 and November 2023.
Article Synopsis
- Vagus nerve stimulation (VNS) shows therapeutic benefits for conditions like epilepsy and depression, but its mechanisms are not fully understood.
- Cervical vagus nerve biopsies revealed right-sided dominance and female predominance in fascicle numbers, alongside diverse fascicle sizes and structures.
- A new tool (HAPI) helped identify the different nerve action potentials from varied nerve fibers, offering insights that could improve VNS treatment strategies.
Article Synopsis
- The study looked at how to manage blood thinners after people got a special heart device called HeartMate 3.
- It compared two methods for checking the right dose of a blood thinner called unfractionated heparin (UFH).
- There were no big differences in bleeding or clotting problems between the two methods, but more research is needed to know which one is better.
Article Synopsis
- Blood donations were screened for high-titre anti-A/B antibodies to minimize the risk of transfusion reactions, focusing on data from Australia and England between 2018-2021.
- Analysis of nearly 6 million donations showed that females, younger donors, and those from certain ethnic backgrounds were more likely to test HT-positive, with a significantly higher rate in Australia compared to England.
- The study concluded that factors like sex, age, ABO blood group, and ethnicity influence HT-positive rates, while differences in testing methods contributed to the variations observed between the two countries.
Background: We report an obstetric case involving an RhD-positive woman who had developed a red blood cell (RBC) antibody that was not detected until after delivery of a newborn, who presented with a positive direct antiglobulin test result. Immunohematology studies suggested that the maternal antibody was directed against a low-prevalence antigen on the paternal and newborn RBCs.
Results: Comprehensive blood group profiling by targeted exome sequencing revealed a novel nonsynonymous single nucleotide variant (SNV) RHCE c.