Differential Gene Set Enrichment of Epithelial-Mesenchymal Transition Pathway in BRAF vs. NRAS Mutated Metastatic Melanoma.

This study investigates the differential activation of the epithelial-mesenchymal transition (EMT) pathway in metastatic melanoma, focusing on BRAF- and NRAS-mutated samples from The Cancer Genome Atlas (TCGA). Gene Set Enrichment Analysis (GSEA) reveals that BRAF mutations are more significantly associated with increased EMT activation, relative to all other mutations in the dataset. In contrast, NRAS mutations were not significantly associated with gene expression of the EMT pathway, suggesting alternative mechanisms for metastasis.

Effect of Fitness Level on Time Course of Recovery After Acute Strength and High-Intensity Interval Training.

Grammenou, M, Kendall, KL, Wilson, CJ, Porter, T, Laws, SM, and Haff, GG. Effect of fitness level on time course of recovery after acute strength and high-intensity interval training. J Strength Cond Res 38(12): 2055-2064, 2024-The aim was to investigate time course of recovery after acute bouts of strength (STR) and high-intensity interval training (HIIT).

Effect of Fitness Level on Time Course of Recovery After Acute Strength and High-Intensity Interval Training.

Grammenou, M, Kendall, KL, Wilson, CJ, Porter, T, Laws, SM, and Haff, GG. Effect of fitness level on time course of recovery after acute strength and high-intensity interval training. J Strength Cond Res XX(X): 000-000, 2024-The aim was to investigate time course of recovery after acute bouts of strength (STR) and high-intensity interval training (HIIT).

Echocardiography-derived regional strain for assessment of non-culprit stenosis and prediction of systolic function recovery in acute STEMI.

To compare echocardiographic regional longitudinal strain with quantitative coronary angiography and assess temporal changes in regional strain in patients with STEMI and multivessel coronary artery disease. Thirty-two patients with STEMI and multivessel coronary artery disease underwent coronary angiography with 3D quantification and baseline echocardiography. Regional longitudinal strain was measured as the average strain of three adjacent myocardial segments (RLS-3S) with the most impaired strain values.