Publications by authors named "T L Koller"
Background And Aims: Alcohol-associated hepatitis (AH) frequently triggers acute decompensation (AD) in cirrhosis, with severe AH linked to high short-term mortality, especially in acute-on-chronic liver failure. Current corticosteroid treatments have limited efficacy, highlighting the need for new therapies. We hypothesized that severe AH outcomes are influenced by early specialized care; thus, we examined the impact of time-to-tertiary care (TTTc).
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- Severe alcohol-associated hepatitis (SAH) is a serious condition with high mortality rates, and current treatments like corticosteroids have limited effectiveness, prompting the exploration of new therapies such as fecal microbiota transplantation (FMT).
- This study aimed to investigate the impact of FMT on 30- and 90-day mortality in SAH patients who did not respond to or were ineligible for corticosteroids, as well as to identify outcomes and factors influencing patient survival.
- The research involved a prospective analysis of adult patients receiving FMT, comparing their outcomes with a control group who received standard care, and evaluating various prognostic factors related to SAH outcomes.
Whole genome sequencing distinguishes skin colonizing from infection-associated isolates.
Front Cell Infect Microbiol
November 2024
Article Synopsis
- The study investigates the role of *Cutibacterium acnes* strains in either colonizing healthy skin or causing infections, noting that the molecular basis for their differing behaviors remains unclear.
- Researchers collected strains from 27 infected individuals and 18 healthy controls, using strict criteria to determine their roles, and compared genomic data for analysis.
- Findings indicated that while colonizing strains clustered separately from most clinical strains, genomic differences related to metabolic pathways and DNA repair, rather than distinct virulence factors, might explain the varying behaviors of these strains.
The paenilamicins are a group of hybrid nonribosomal peptide-polyketide compounds produced by the honey bee pathogen Paenibacillus larvae that display activity against Gram-positive pathogens, such as Staphylococcus aureus. While paenilamicins have been shown to inhibit protein synthesis, their mechanism of action has remained unclear. Here we determine structures of paenilamicin PamB2-stalled ribosomes, revealing a unique binding site on the small 30S subunit located between the A- and P-site transfer RNAs (tRNAs).
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