Publications by authors named "T L Hudson"
Article Synopsis
- Patients on long-term opioid therapy for chronic pain often still suffer from unrelieved pain and quality of life issues.
- This study compared two approaches for managing these patients: an integrated pain team (IPT) focused on holistic care versus pharmacist collaborative management (PCM) concentrated on medication optimization.
- Results showed similar outcomes for both groups in terms of pain response and opioid dosage reduction after 12 months, indicating that both methods can be effective in managing chronic pain.
Article Synopsis
- Researchers discovered a strong and selective antagonist for the lysophosphatidic acid receptor 1 (LPAR1), which has antifibrotic properties, initially validated through a specific assay involving MRTF-A.* -
- Structural modifications improved the compound's stability and pharmacokinetics, leading to a promising candidate for oral dosing that effectively blocked LPA-induced histamine release and showed efficacy against lung fibrosis in preclinical tests.* -
- Despite its potential, the development of the LPAR1 antagonist was discontinued due to observed CNS toxicity in dog models, raising safety concerns for clinical use in idiopathic pulmonary fibrosis (IPF).*
Article Synopsis
- The study investigates how Janus rods self-assemble and behave in different phases by using Langevin dynamics simulations and free energy calculations across various temperatures and concentrations.
- The Janus rods are made up of overlapping spheres, some of which have attractive features, and their assembly leads to various structures depending on the coverage of these attractive sites.
- At lower densities, structures like spherical and tubular micelles form, while at higher densities, more complex arrangements like bilayer and smectic phases emerge, showcasing a variety of structural possibilities that could inform the design of new rod-like materials.
Primary Stapedectomy: A Retrospective Review of Surgical Results Using a Cold Steel Technique and Pre-Operative CT Correlates.
J Otolaryngol Head Neck Surg
October 2024
Importance: Stapedectomy is an effective treatment option for patients with symptomatic otosclerosis. A common surgical technique today is laser stapedotomy, although the equipment required adds a significant cost to the procedure and may not be available in certain, particularly remote, centers. This study aimed to evaluate cold steel stapedectomy in a modern otology practice as a cost-effective and versatile alternative.
View Article and Find Full Text PDFObjective: To report opioid prescription patterns after pediatric anterior cruciate ligament reconstruction (ACLR) and identify if the implementation of the opioid prescribing guidelines (OPGs) modified these patterns.
Design: A retrospective chart review.
Setting: Level 1 Pediatric Trauma Center.