Publications by authors named "T L Ferrell"
Background: On 11 March 2020, COVID-19 was declared a global health pandemic by the World Health Organization (WHO). Vaccinating populations is paramount in changing the course of a pandemic. The rapid spread of (mis) and disinformation online from celebrities, politicians, and media influencers creates a corrosion of trust in public health interventions.
View Article and Find Full Text PDFPerioperative dysfunction of the fibrinolytic system may play a role in adverse outcomes for liver transplant recipients. There is a paucity of data describing the potential impact of the postoperative fibrinolytic system on these outcomes. Our objective was to determine whether fibrinolysis resistance (FR), on postoperative day one (POD-1), was associated with early allograft dysfunction (EAD).
View Article and Find Full Text PDFGenetic analysis of intra-host viral populations provides unique insight into pre-emergent mutations that may contribute to the genotype of future variants. Clinical samples positive for SARS-CoV-2 collected in California during the first months of the pandemic were sequenced to define the dynamics of mutation emergence as the virus became established in the state. Deep sequencing of 90 nasopharyngeal samples showed that many mutations associated with the establishment of SARS-CoV-2 globally were present at varying frequencies in a majority of the samples, even those collected as the virus was first detected in the US.
View Article and Find Full Text PDFArticle Synopsis
- Persistent ascites (PA) after liver transplant (LT) is a common issue that is linked to platelet count and function.
- A study of 105 LT recipients found that 28% experienced PA, with factors like platelet transfusions and low clot strength contributing to this condition.
- Patients with PA not only stayed longer in the hospital but also had a higher likelihood of suffering from intraabdominal infections.
Background: Infection is a leading cause of morbidity in liver transplant (LT). Considering that the fibrinolytic system is altered in sepsis, we investigated the relationship between fibrinolysis resistance (FR) and post-transplant infection.
Methods: Fibrinolysis was quantified using thrombelastography (TEG) with the addition of tPA to quantify FR.