Publications by authors named "T L Duran"
Oxadiazole compounds are of great interest because they have a range of biological activities ranging from antioxidants to anticancer agents. Against this background, we wanted to demonstrate the antioxidant, enzyme inhibitory, and anticancer effects of 5(4-hydroxyphenyl)-2-(N-phenylamino)-1,3,4-oxadiazole (Hppo). Antioxidant abilities were measured through free radical scavenging and reducing power tests.
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- * New cell-tethering and hypoxic conditioning colloidal hydrogels, which contain mesenchymal stem cells (MSCs), help retain cells and improve local delivery of healing factors over time.
- * In experiments, these hydrogels not only improved cell retention and oxygen supply but also led to better blood flow restoration and muscle healing in a mouse model of hindlimb ischemia.
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- ICF syndrome is a rare, autosomal recessive disease linked to mutations in specific genes (DNMT3B, ZBTB24, CDCA7, HELLS) that lead to immune deficiencies and facial anomalies.
- This study examined the expression of transcription factors and cytokines in various helper T cell subsets from ICF patients and found significant reductions in these factors compared to healthy controls.
- It also identified a novel mutation in the ZBTB24 gene related to ICF2 syndrome, marking the first molecular investigation of T cell subsets in ICF syndrome.
Spondyloarthritis (SpA) is a term to describe a group of chronic inflammatory rheumatic diseases, which have common pathophysiological, genetic, and clinical features. Under the umbrella term SpA, two main groups are subsumed: axial SpA (radiographic axSpA and non-radiographic axSpA) and peripheral SpA (with the leading representative being psoriatic arthritis (PsA) but also arthritis associated with inflammatory bowel disease (IBD), reactive arthritis, and undifferentiated pSpA). The key clinical symptom in axSpA is chronic back pain, typically with inflammatory characteristics, which starts in early adulthood, while the leading clinical manifestations of peripheral SpA (pSpA) are arthritis, enthesitis, and/or dactylitis.
View Article and Find Full Text PDFThe study aimed to investigate the expression profiles of transcription factors, cytokines, and co-stimulatory molecules in helper T (Th)-cell subsets within bronchoalveolar lavage (BAL) samples of patients with interstitial lung diseases (ILDs). Twenty ILDs patients were included in the study, comprising those with idiopathic pulmonary fibrosis (IPF) (n:8), autoimmune-related ILDs (auto-ILD) (n:4), and orphan diseases (O-ILD) (n:8), alongside five control subjects. Flow cytometry was employed to evaluate the Th to cytotoxic T cell (CTL) ratio in BAL fluid, while cytopathological examination assessed macrophages, lymphocytes, and neutrophils.
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