Publications by authors named "T L Cover"
colonizes a majority of the human population worldwide and can trigger development of a variety of gastric diseases. Since the bacterium is classified as a carcinogen, elucidation of the characteristics of that influence gastric carcinogenesis is a high priority. To this end, the Mongolian gerbil infection model has proven to be an important tool to study gastric cancer progression.
View Article and Find Full Text PDFColonization of the human stomach with strains producing active forms of the secreted toxin VacA is associated with an increased risk of peptic ulcer disease and gastric cancer, compared with colonization with strains producing hypoactive forms of VacA. Previous studies have shown that active s1m1 forms of VacA cause cell vacuolation and mitochondrial dysfunction. In this study, we sought to define the cellular metabolic consequences of VacA intoxication.
View Article and Find Full Text PDFArticle Synopsis
- The study focuses on the structural and proteomic analysis of Cag T4SSs derived from deletion mutants.
- It emphasizes the surprising structural independence between two key subdomains: the outer membrane complex (OMC) and the pilot region (PR).
- This finding challenges previous assumptions about the interdependence of these components within the T4SS structure.
Article Synopsis
- * The OMCC consists of a 14-fold symmetric outer membrane cap (OMC), a 17-fold symmetric periplasmic ring (PR), and an undefined stalk, with specific proteins (CagY, CagX, CagM, CagT) involved in organization.
- * Cryo-electron microscopy revealed that while the PR maintains structure without some proteins, the OMC’s organization requires multiple proteins, indicating a structural independence between the OMC and PR within the Cag T4SS
Article Synopsis
- Strains of bacteria can be categorized into two groups based on the presence of a pathogenicity island (PAI), which influences their impact on human health.
- Colonization of the stomach by PAI-positive strains is linked to a higher risk of gastric cancer and peptic ulcers compared to PAI-negative strains.
- The PAI encodes a protein called CagA and a secretion system that helps deliver CagA into host cells, which triggers inflammation and contributes to gastric diseases.