Publications by authors named "T L Coimbra"
Article Synopsis
- The study investigated how the immunodominance of the egg antigen Sm-p40 affects the immune response and liver disease severity in schistosomiasis using a mouse model.
- Mice were treated with specific epitope combinations to observe the effects on liver granuloma size and CD4+ T cell behavior, revealing that strong immunodominance leads to harmful immune polarization.
- The findings suggest that managing immunodominance could enhance CD4+ T cell modulation, potentially providing a treatment strategy for schistosomiasis and similar diseases.
Background: Activation of the mitogen-activated protein kinase (MAPK) pathway induces uncontrolled cell proliferation in response to inflammatory stimuli. Adriamycin (ADR)-induced nephropathy (ADRN) in rats triggers MAPK activation and pro-inflammatory mechanisms by increasing cytokine secretion, similar to chronic kidney disease (CKD). Activation of the vitamin D receptor (VDR) plays a crucial role in suppressing the expression of inflammatory markers in the kidney and may contribute to reducing cellular proliferation.
View Article and Find Full Text PDFHyperglycemia is a major risk factor for kidney diseases. Oxidative stress, caused by reactive oxygen species, is a key factor in the development of kidney abnormalities related to hyperglycemia. The nuclear factor erythroid 2-related factor-2 (Nrf2) plays a crucial role in defending cells against oxidative stress by activating genes that produce antioxidants.
View Article and Find Full Text PDFChallenges in the care of children born to mothers diagnosed with COVID-19 during the pandemic.
Rev Gaucha Enferm
November 2023
Objective: To understand the challenges in the care of children born to mothers with COVID-19 during the pandemic.
Method: Qualitative research, conducted from November 2020 to May 2021, in two public maternity hospitals, with women who had children during the first wave of the pandemic, diagnosed with COVID-19 during pregnancy and/or childbirth. There were nineteen semi-structured interviews with thematic analysis.
Maternal health during the COVID-19 pandemic: Experiences of health workers in three Brazilian municipalities.
PLoS One
August 2023
Objective: To analyze the experiences of maternal health workers in three Brazilian cities, located in the Northeast (São Luís), Southeast (Niterói), and South (Pelotas) regions during the first year of the COVID-19 pandemic.
Methods: Qualitative research carried out between December 2020 and February 2021. Interviews were conducted, in person or remotely, with 30 health workers, doctors and nurses, working in maternity hospitals of different degrees of complexity.