Publications by authors named "T L Cascino"
Patients 65 years of age or older represent the fastest-growing demographic group added to the U.S. heart transplant (HT) list.
View Article and Find Full Text PDFBackground: Heart transplantation (HT) survival and waitlist times are established outcome metrics. Patient-centered HT outcomes are insufficiently characterized. This study evaluates the role of days alive and outside the hospital (DAOH) as a candidate patient-centered HT performance measure.
View Article and Find Full Text PDFArticle Synopsis
- - Of the 5 randomized controlled trials (RCTs) analyzed, 20% of participants had chronic thromboembolic pulmonary hypertension (CTEPH), but none specifically studied the impacts of exercise training in these patients.
- - The study suggests that exercise training can enhance exercise capacity in pulmonary hypertension (PH) patients, specifically indicated by improvements in 6-minute walk distance.
- - It also highlights that exercise training appears to be safe for patients with CTEPH and pulmonary arterial hypertension (PAH), challenging the common belief that exercise is risky for these individuals.
The 15th Annual Report from The Society of Thoracic Surgeons Interagency Registry for Mechanically Assisted Circulatory Support includes 29,634 continuous-flow left ventricular assist devices from the 10-year period between 2014 and 2024. The outcomes reported here demonstrate continued improved survival in the current era of fully magnetically levitated devices, with a significantly higher 1-year (85.7% vs 78.
View Article and Find Full Text PDFA new day has come: Sotatercept for the treatment of pulmonary arterial hypertension.
J Heart Lung Transplant
January 2025
Article Synopsis
- Despite advancements in treatments for pulmonary arterial hypertension (PAH), patients still face high rates of illness and death.
- Sotatercept, a new therapy that inhibits activin signaling, has been approved for PAH and shows promising efficacy and safety.
- The review provides insights into how Sotatercept works, its benefits for patient wellbeing and survival, and its safety profile to better inform readers about this innovative treatment.