Ocean ecosystems have been subjected to anthropogenic influences for centuries, but the scale of past ecosystem changes is often unknown. For centuries, the European flat oyster (Ostrea edulis), an ecosystem engineer providing biogenic reef habitats, was a culturally and economically significant source of food and trade. These reef habitats are now functionally extinct, and almost no memory of where or at what scales this ecosystem once existed, or its past form, remains.
View Article and Find Full Text PDFCold plasma of ionospheric origin has recently been found to be a much larger contributor to the magnetosphere of Earth than expected. Numerous competing mechanisms have been postulated to drive ion escape to space, including heating and acceleration by wave-particle interactions and a global electrostatic field between the ionosphere and space (called the ambipolar or polarization field). Observations of heated O ions in the magnetosphere are consistent with resonant wave-particle interactions.
View Article and Find Full Text PDFBackground: The Centers for Medicare and Medicaid Services (CMS) are currently negotiating prices with pharmaceutical manufacturers for the first 10 Part D drugs selected for Medicare drug price negotiation. Non-publicly available data, including the net prices of selected drugs and their therapeutic alternatives, will play a central role in the determination of the maximum fair prices (MFPs).
Objective: To estimate price benchmarks involved in the derivation of the starting point of the CMS initial price offer for the 10 drugs selected for Medicare price negotiation.