Publications by authors named "T L Bryan"
Ebola virus (EBOV) causes severe disease in humans, with mortality as high as 90%. The small-molecule antiviral drug remdesivir (RDV) has demonstrated a survival benefit in EBOV-exposed rhesus macaques. Here, we characterize the efficacy of multiple intravenous RDV dosing regimens on survival of rhesus macaques 42 days after intramuscular EBOV exposure.
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- The study explores the prevalence of depression and self-harm risk among adolescents in pediatric orthopaedic sports clinics, utilizing the PHQ-2 and PHQ-9 questionnaires as assessment tools.
- Findings indicate that 4.2% of patients screened positive for depression, with self-harm risk notably higher in those with shoulder injuries and knee instability, especially among Black/African American youth and females.
- The research suggests that certain demographic factors and specific injuries may predict higher self-harm risks, highlighting the need for mental health assessments in sports-related injury contexts.
Article Synopsis
- The study aimed to analyze how changes in upper lumbar lordosis after spinal fusion affect the alignment of unfused lower lumbar segments in patients with Adolescent Idiopathic Scoliosis.
- A retrospective review was conducted on 158 patients who underwent posterior spinal fusion, focusing on various spinal measurements and using MATLAB for 3D calculations.
- Results indicated that increased upper lumbar lordosis influenced the lordotic shape of distal unfused segments, with varying impacts based on the specific levels of fusion, while overall sagittal alignment remained stable.
Background: Avulsion fractures of the sublime tubercle of the ulna are a cause of medial elbow pain and instability in overhead athletes.
Purpose: To compare outcomes after sublime tubercle avulsion fracture managed as a fracture (with cast immobilization) versus a soft tissue injury (without immobilization and with early range of motion [ROM]) to determine how to achieve the best outcomes for these injuries in adolescent throwing athletes.
Study Design: Cohort study; Level of evidence, 3.
Telomere maintenance and the DNA damage response: a paradoxical alliance.
Front Cell Dev Biol
October 2024
Telomeres are the protective caps at the ends of linear chromosomes of eukaryotic organisms. Telomere binding proteins, including the six components of the complex known as shelterin, mediate the protective function of telomeres. They do this by suppressing many arms of the canonical DNA damage response, thereby preventing inappropriate fusion, resection and recombination of telomeres.
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