Publications by authors named "T L Ajith"
Verona-integron-metallo-β-lactamase (VIM-2) is one of the most widespread class B β-lactamase responsible for β-lactam resistance. Although active-site residues help in metal binding, the residues nearing the active-site possess functional importance. Here, to decipher the role of such residues in the activity and stability of VIM-2, the residues E146, D182, N210, S207, and D213 were selected through in-silico analyses and substituted with alanine using site-directed mutagenesis.
View Article and Find Full Text PDFAlzheimer's disease (AD), one of the most prevalent neurodegenerative disease responsible for 60%-80% dementia cases globally. The disease is more prevalent among elder females. Female reproductive hormones are found to be essential for cellular activities in brain.
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- This study examines new particle formation (NPF) events in Rehovot, Israel, during two campaigns, focusing on particle size, composition, and gaseous pollutants.
- Researchers identified major sources of organic aerosols from hydrocarbons and biomass burning, and observed significant daytime and nighttime NPF events linked to photochemistry and other chemical species.
- A hybrid positive matrix factorization analysis revealed that various components, like ammonium sulfate and different organic aerosol types, play key roles in both nucleation and particle growth processes during these events.
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- Early Pregnancy Loss (EPL) significantly impacts women's physical and psychological health, yet there is a lack of guided hospital support services in the UK, making the evaluation of an Early Pregnancy Loss Support Clinic (EPLSC) crucial.
- The evaluation gathered quantitative data using questionnaires to measure patient satisfaction and anxiety levels, alongside qualitative insights from interviews focusing on women’s health experiences and support needs.
- Results showed high satisfaction rates among the 110 women who attended the EPLSC, with many reporting reduced anxiety and emphasizing the importance of emotional support and the role of the bereavement midwife.
Prevention of anticancer drugs-induced cardiotoxicity remains an imperative area of oncology research as it continues to be a major challenge in cancer chemotherapy. This study was undertaken to investigate the protective effect of methanol extract of Morchella esculenta (ME) against cyclophosphamide (CP)-induced cardiotoxicity. Myocardial damage was assessed by biochemical and histopathological methods.
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