Publications by authors named "T Kurosu"
Severe fever with thrombocytopenia syndrome (SFTS) in Thailand: using a one health approach to respond to novel zoonosis and its implications in clinical practice.
One Health Outlook
October 2024
Article Synopsis
- Severe fever with thrombocytopenia syndrome (SFTS) is a tick-borne disease caused by Dabie bandavirus, first reported in Thailand in 2019.
- The study highlights a One Health investigation, revealing that domestic dogs and cats may act as potential reservoirs for the virus, while no SFTSV was found in local ticks or wild animals.
- The authors emphasize the need for integrated surveillance using genomic and serologic methods to better understand SFTS and prevent its spread among humans and animals in East Asia.
Dengue is a global health concern, and the host-viral interactions that regulate disease severity are largely unknown. Detrimental effects of neutrophils in this disease have been reported, but the precise mechanisms and functional properties of dengue-activated neutrophils are not fully characterised. Here, we measured the effects of dengue virus serotype 3 (DV3) on neutrophil lifespan and functions.
View Article and Find Full Text PDFSevere fever with thrombocytopenia syndrome (SFTS) virus, a tick-borne bunyavirus, causes a severe/fatal disease termed SFTS; however, the viral virulence is not fully understood. The viral non-structural protein, NSs, is the sole known virulence factor. NSs disturbs host innate immune responses and an NSs-mutant SFTS virus causes no disease in an SFTS animal model.
View Article and Find Full Text PDFArticle Synopsis
- - The study aimed to validate the use of endoscopic ultrasound-guided tissue acquisition (EUS-TA) combined with stereomicroscopic on-site evaluation (SOSE) as a diagnostic tool for identifying resectable pancreatic cancer (R-PC) and borderline resectable pancreatic cancer (BR-PC).
- - A total of 78 patients undergoing EUS-TA were analyzed, with a focus on achieving a specific sensitivity based on a stereomicroscopic measurement called the white core cutoff value; results showed a high sensitivity of 90.4% for diagnosing malignancies.
- - The study concluded that EUS-TA with SOSE is a reliable method for diagnosing malignant lesions, demonstrating high overall sensitivity (90.8%), specificity
Introduction: Severe dengue is thought to be caused by an excessive host immune response.
Methods: To study the pathogenesis of severe dengue, we developed a novel model using LysM Cre mice carrying depleted expression only in subsets of murine myeloid cells.
Results: Although dengue virus (DENV) clinical isolates were not virulent in LysM Cre mice, mouse-adapted DV1-5P7Sp and DV3P12/08P4Bm, which were obtained by passaging the spleen or bone marrow of mice, demonstrated 100% lethality with severe vascular leakage in the liver and small intestine.