New data on thymus pathophysiology in children.

The results of clinical-roentgenological and hormonal-immunological studies showed that immunohomeostasis peculiarities and adaptation in children with thymomegaly and pneumonia-complicated thymomegaly are determined by prolonged 'metabolic stress' effect associated with thymomegaly and coexistent intercurrent infection. Immune control of children with thymomegaly is appreciably determined by the hormonal function of hypothalamus-hypophysis-thymus-adrenal cortex system and by optimum balance of its constituents. Hypothalamic-hypophysial-adrenal system, cAMP and cGMP as universal intracellular mediators, and, essentially, thymus hormonal function are basic contributors to immunohomeostatis and adaptive reaction control in children with thymomegaly.

[The pituitary-adrenal system and cortisol-resistant lymphocyte fraction in infants with acute pneumonia].

Changes in ACTH, STH, cortisol and in the cortisol-resistant lymphocyte fraction in the blood were studied in infants with different patterns and gravity of acute pneumonia. The dynamic changes in stressor-adaptive reactions and the magnitudes of the cortisol-resistant lymphocyte population attest to opposite changes in lymphocytes and in the adrenocortical system. The quantitative changes in the cortisol-resistant lymphocyte fraction determine the prospects of optimizing the principles of the steroid therapy in the pathology indicated.

[The efficacy of using thymalin in diabetes mellitus in children].

A possibility of the use of thymalin was studied in children with diabetes mellitus using adequate immunohormonal investigations. Clinico-metabolic investigations proved the efficacy of the use of the new immunomodulator thymalin in multimodality therapy of diabetes mellitus in children.