Publications by authors named "T Kumabe"
Purpose: Glioblastomas contacting the subventricular zone (SVZ) are associated with poor prognosis and the impact of ventricular entry (VE) during resection remains controversial. Since glioblastomas with SVZ involvement often require VE, both SVZ involvement and VE are confounding factors. This study aimed to evaluate the effect of VE during glioblastoma resection by comparing patients with and without SVZ involvement.
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- Glioblastoma (GB) is highly invasive, and the study investigates the origins and molecular characteristics of butterfly glioblastoma (bGB) by analyzing a cohort of 34 bGB patients alongside others from public datasets.
- The results show that bGB can arise from two distinct origins—corpus callosum (CC) and cerebral hemisphere—with unique molecular mutations and prognostic implications, particularly identifying the CC-type as having worse survival outcomes.
- The study emphasizes the need for further research to understand the clinical significance and differences between the identified bGB subtypes to enhance treatment strategies and patient care.
Background: To improve the outcome in newly diagnosed glioblastoma patients with maximal resection, we aimed to evaluate the efficacy and safety of implantation of carmustine wafers (CWs), radiation concomitant with temozolomide and bevacizumab, and maintenance chemotherapy with six cycles of temozolomide and bevacizumab.
Method: This prospective phase II study enrolled glioblastoma patients considered candidates for complete resection (> 90%) of a contrast-enhanced lesion. The CWs were intraoperatively implanted into the resection cavity after achieving maximal resection.
Occipital lobectomy is a widely accepted procedure for treatment of occipital gliomas and occipital lobe epilepsy, but its technical nuances are not well discussed. Anatomically, the occipital lobe, also known as the cuneus or visual area, is an isolated region in terms of vascular supply. The terminal branches of posterior cerebral arteries, including parieto-occipital and calcarine arteries, are the major vessels supplying this region.
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- - The study investigated the significance of residual hyperintense areas on T2-weighted MRI in glioblastoma patients after initial treatment, involving surgery, radiotherapy, and temozolomide.
- - Out of 150 cases, 77 were analyzed, revealing that 71.4% had residual hyperintense areas post-treatment, with a median progression-free survival of 12.4 months and overall survival of 27.4 months; however, these areas were not indicative of prognosis.
- - Results showed that local recurrences aligned with residual hyperintense areas, while the T2D group (without these areas) experienced more distant recurrences, highlighting the need for targeted monitoring of both groups based on their