Publications by authors named "T Kuloglu"
Objective: Fractalkine (CX3CL1) and macrophage inflammatory protein-1β (MIP-1β)/CCL4 play a role in chemotactic activity, immune response, and inflammatory response. We aimed to investigate the effects of fractalkine and MIP-1β in the development of ovarian hyperstimulation syndrome (OHSS) by considering the inflammatory response during ovulation.
Materials And Methods: Two equal groups of 20 immature female rats were created.
Objectives: To determine the effects of hyperandrogenemia and other phenotypic parameters on endometrial vitamin D receptor (VDR-X2 and VDR-X4) expression in women with polycystic ovary syndrome (PCOS) undergoing ovarian stimulation and total embryo freezing.
Methods: Forty-four PCOS patients were divided into four phenotypes according to the criteria for hyperandrogenemia (HA), ovulatory dysfunction (OD), and polycystic ovary morphology (PCOM): phenotype A (HA+OD+PCOM), phenotype B (HA+OD), phenotype C (HA+PCOM), and phenotype D (OD+PCOM). Endometrial VDR expression was determined by real-time PCR and immunohistochemistry.
Introduction: Breast cancer is one of the most common malignant tumors and a leading cause of cancer-related death in women. Research is focusing on biomarkers linked to breast cancer, particularly two novel proteins: isthmin-1 (ISM-1) and spexin (SPX), which require further investigation.
Material And Methods: The study involved 20 healthy controls and 60 patients with invasive ductal carcinoma, categorized into three groups: Grade I (n=20), Grade II (n=20), and Grade III (n=20).
Backround: In this study, we aimed to investigate the potential contributions to the disease by examining the immunoreactivities of SPX in LP-affected skin tissue using immunohistochemical methods, in light of its recent prominence as a molecule related to diabetes mellitus, along with apoptosis and ferroptosis mediated by GPX4 and TRPM2 channels facilitating oxidative stress-induced cell death.
Objective: This research explored the immunohistochemical expressions of TRPM2, GPX4, and SPX in Lichen Planus (LP) patients compared to healthy individuals.
Materials And Methods: Forty skin samples were collected, split equally between LP patients and healthy controls, excluding those with other conditions.
Article Synopsis
- - This study compares chronic immobilization stress (CIS) and cisplatin treatments as models for studying premature ovarian failure (POF) in rats, focusing on their effects on ovarian function and the potential benefits of a mitochondrial protective agent (AP39).
- - Sixty female rats were divided into six groups to assess different treatment combinations and evaluate factors like hormonal levels, estrous cycles, and ovarian health through various tests and observations.
- - The results showed that both CIS and cisplatin treatments led to significant declines in ovarian health markers, and AP39 did not fully return these parameters to normal, suggesting that the CIS model may better represent stress-induced ovarian dysfunction rather than typical POF.