Publications by authors named "T Kuga"
Article Synopsis
- Granulocyte/monocyte adsorption therapy can help treat mild-to-moderate inflammatory bowel disease by removing activated immune cells, and its efficacy was tested using new columns designed for better adsorption.
- In a study with rats suffering from colitis, the new columns led to improved tissue health but didn’t significantly enhance the rate of immune cell adsorption into the blood.
- The therapy was associated with an increase in newly formed B cells that produced higher levels of interleukin-10, suggesting they play a role in reducing inflammation and controlling colitis symptoms.
Purpose Postoperative pain management methods for tonsillectomy commonly include the use of opioids, non-steroidal anti-inflammatory drugs, and acetaminophen. However, some patients report pain despite the use of these medications. In recent years, ultrasound-guided selective glossopharyngeal nerve block (UGSGNB) and ultrasound-guided maxillary nerve block (UGMNB) have been reported to be effective for analgesia post-tonsillectomy.
View Article and Find Full Text PDFType I interferons (IFN-Is) play a significant role in systemic lupus erythematosus (SLE) pathogenesis. Double-filtration plasmapheresis (DFPP) is a treatment option for SLE; however, its effect on IFN-Is remains unclear. Therefore, we investigated the effects of DFPP on IFN-Is.
View Article and Find Full Text PDFEffect of Free Cysteine Residues to Serine Mutation on Cellodextrin Phosphorylase.
J Appl Glycosci (1999)
May 2024
Cellodextrin phosphorylase (CDP) plays a key role in energy-efficient cellulose metabolism of anaerobic bacteria by catalyzing phosphorolysis of cellodextrin to produce cellobiose and glucose 1-phosphate, which can be utilized for glycolysis without consumption of additional ATP. As the enzymatic phosphorolysis reaction is reversible, CDP is also employed to produce cellulosic materials However, the enzyme is rapidly inactivated by oxidation, which hinders utilization in aerobic environments. It has been suggested that the cysteine residues of CDP, which do not form disulfide bonds, are responsible for the loss of activity, and the aim of the present work was to test this idea.
View Article and Find Full Text PDFArticle Synopsis
- Enhanced IFNα production is linked to the development of systemic lupus erythematosus (SLE), particularly through the activation of the STING pathway in monocytes from SLE patients.
- Research showed that SLE monocytes exhibited increased expression of GATA4, which elevates IFNα production and is associated with markers of cellular senescence like CDKN2A.
- The study concluded that GATA4 plays a crucial role by binding to the enhancer regions of IFIT genes, thereby boosting the production of type I interferons, which are elevated in the context of SLE.