X-linked hypophosphataemia.

X-linked hypophosphataemia is a rare genetic disorder that causes renal phosphate wasting, impaired mineralisation of teeth and bones, skeletal deformities and limited mobility, all of which significantly impact on health and quality of life. This clinical review examines the recommendations for diagnosing, treating and monitoring adults with the condition.

DOG1 controls dormancy independently of ABA core signaling kinases regulation by preventing AFP dephosphorylation through AHG1.

Seed dormancy determines germination timing, influencing seed plant adaptation and overall fitness. DELAY OF GERMINATION 1 (DOG1) is a conserved central regulator of dormancy cooperating with the phytohormone abscisic acid (ABA) through negative regulation of ABA HYPERSENSITIVE GERMINATION (AHG) 1 and AHG3 phosphatases. The current molecular mechanism of DOG1 signaling proposes it regulates the activation of central ABA-related SnRK2 kinases.

Investigating brain activity at rest in patients with persistent genital arousal disorder (PGAD) using functional magnetic resonance imaging.

Persistent genital arousal disorder (PGAD) is a rare disease causing high emotional distress eminently impacting the individual's quality of life. Experts in this field assume that the disease is caused by a multifaceted interplay of different etiologies which may share a common neurobiological basis. However, only one functional neuroimaging investigation exist, and a more in-depth comprehension of the neurobiological foundation is required.

Subcellular dynamics in unicellular parasites.

Bioimaging has made tremendous advances in this century. Innovations in high- and super-resolution microscopy are well established, and live-cell imaging is extensively used to gain an overview of dynamic processes. But the combination of high spatial and temporal resolution necessary to capture intracellular dynamics is rarely achieved.