Publications by authors named "T Krarup"
Background: Dyslipidemia with elevated concentrations of triacylglycerol-rich lipoproteins (TRLs), small-dense LDL, and reduced HDL is linked to hepatic steatosis and promotes atherogenesis in type 2 diabetes (T2D).
Objectives: We aimed to analyze whether moderate carbohydrate restriction reduces liver fat in T2D independent of changes in body weight and whether this is accompanied by parallel improvements in plasma lipoprotein subclasses.
Methods: We determined the density profile of circulating lipoproteins in patients with T2D from 2 previous randomized controlled trials.
Aim: To test the effect of the glucagon-like peptide-1 receptor agonist, liraglutide, on residual beta-cell function in adults with newly diagnosed type 1 diabetes.
Materials And Methods: In a multicentre, double-blind, parallel-group trial, adults with newly diagnosed type 1 diabetes and stimulated C-peptide of more than 0.2 nmol/L were randomized (1:1) to 1.
Context: Studies in heterogenous groups of people with respect to sex, body mass index (BMI), and glycemic status (normoglycemia, impaired glucose tolerance, diabetes), indicate no relationship between liver fat accumulation and pancreatic insulin secretion.
Objective: To better understand the association of liver fat with insulin secretion.
Methods: Cross-sectional analysis of 61 men with abdominal obesity who had high liver fat (HLF, ≥5.
Article Synopsis
- The management of type 2 diabetes (T2D) emphasizes lifestyle changes, particularly a healthy diet that comprises 45%-60% carbohydrates, but low-carb diets have shown improved short-term glycaemic control compared to higher-carb diets.
- A 12-month randomized controlled trial will assess the effects of a carbohydrate-reduced high-protein (CRHP) diet versus a conventional diabetes (CD) diet on glycaemic control in individuals with T2D, focusing on dietary adherence through meal kits and nutrition education.
- The trial, involving 100 participants and monitored by registered dietitians, has received ethical approval and aims to enhance understanding of sustainable dietary practices for long-term management of T2D.
Context: Fibroblast growth factor 21 (FGF21) and growth differentiation factor 15 (GDF15) are increased in type 2 diabetes and are potential regulators of metabolism. The effect of changes in caloric intake and macronutrient composition on their circulating levels in patients with type 2 diabetes are unknown.
Objective: To explore the effects of a carbohydrate-reduced high-protein diet with and without a clinically significant weight loss on circulating levels of FGF21 and GDF15 in patients with type 2 diabetes.