[Use of ceftriaxone in urinary and respiratory tract infections].

Efficiency of ceftriaxone (Rocephin Hoffman Laroche) was assessed in 16 children aged between 3 and 14 years and in 4 adults aged between 17 and 70 years with severe infections of the urinary and respiratory tracts caused by E. coli. S.

Cerebral blood flow (CBF) autoregulation in spontaneously hypertensive rats (SHR) during chronic administration of a theophylline derivative (P-23).

Chronic hypertension causes the lower and upper limits of CBF autoregulation to reset to higher blood pressure levels. In the present study we examined whether the theophylline derivative P-23, which had lowered blood pressure in SHR, would influence CBF autoregulation. P-23 (10 mg/kg po) was administered once daily for 4 weeks and tail systolic pressure was measured weekly in this P-23 group and in a control group of SHR.

The role of sympathetic nervous system in the action of dopamine and dobutamine on the function of circulatory system.

To assess the role of peripheral structures of the sympathetic nervous system in the effects of dopamine and dobutamine on some functions of the cardiovascular system, experiments were carried out on anesthetized rabbits in which the blood flow in calf muscles was measured, during rest and during evoked twitches, using the method of 133Xe clearance. The arterial blood pressure and ECG were simultaneously recorded. A complete reversal of the action of dopamine on the arterial blood pressure and heart rate, after sympathetic nerve endings blockade, indicates an important role for the undisturbed neurotransmission in revealing hypotensive properties of this amine.

The effect of dopamine on blood flow in skeletal muscles.

To explain some mechanisms of the peripheral action of dopamine experiments were carried out on anesthetized rabbits in which the blood flow in calf muscles was measured during rest and during evoked twitches, using the method of 133Xe clearance of Lassen et al.; the arterial blood pressure and ECG were simultaneously recorded. Dopamine reduced the blood flow, particularly after a muscular effort.