Bullous Henoch-Schönlein Purpura and Associated Nephritis: A Pathological Case Report.

Henoch-Schönlein purpura (HSP) is the most common vasculitis in childhood, presenting with purpura, predominantly of the lower extremities and occasionally with renal involvement as well. Although associated with childhood, HSP, although rarely, can also develop in adults as well. Here we present a patient in his sixties, presenting with a myriad of rash units on his lower extremities, including bullous ones, and a constellation of chronic kidney failure.

Myeloproliferative Neoplasm and Myelodysplastic Syndrome-Associated Renal Disease: A Histopathological Report of Two Cases.

Myeloproliferative neoplasms (MPN) are clonal disorders of hematopoietic stem cells with a proliferation of one or more myeloid lineage and mature cell overproduction, while myelodysplastic syndrome (MDS)/MPN simultaneously show aspects of MDS and MPN, leading to partially ineffective hematopoiesis with associated dysplastic changes. This spectrum of disorders includes chronic myeloid leukemia, polycythemia vera, primary myelofibrosis, and essential thrombocythemia. MDS/MPN are classically not associated with renal complications; however, an accumulating body of evidence suggests that multiple growth factors, cytokines, endothelial damage, and an activated complement system in these patients can induce glomerulopathy, as nearly a third of these patients present with advanced renal disease on diagnosis, which is unlikely to be age or hypertension-related.

[The direct health effects of air pollution in Vratsa in 1991].

The effect of air pollution in the town of Vratsa on the daily morbidity of the population has been studied during the first half of 1991. Studies are performed on the correlation between the daily dynamics in the pollution according to specific for the town indices ammonia, hydrogen sulfide, sulphur dioxide, nitric oxides, dust, meteorological parameters temperature of the air, relative humidity, air velocity, barometric pressure and some respiratory and allergic diseases among the population. It is already established that the level of the air pollution in the town of Vratsa, among which dominate ammonia and hydrogen sulfide, have a direct effect on the acute respiratory morbidity, more expressed among the children.

[The side effects of drugs].

The study is based on the statistical data of 3317 hospitalized patients 310 of whom (9.34%) were hospitalized because of a drug untoward reaction. The drug side effects are more frequent in women (60.