Untreated and uncontrolled hypertension in Japanese patients with spontaneous intracerebral hemorrhage.

Hypertension (HT) is the most attributable and modifiable risk factor for spontaneous intracerebral hemorrhage (SICH). However, epidemiological data on blood pressure (BP) control before SICH and its relationship to patient lifestyles are lacking. This study prospectively enrolled patients with acute SICH from six stroke centers in Tochigi, Japan.

Two Distinct Atrial Breakthroughs During Fast-Slow Atrioventricular Nodal Reentrant Tachycardia.

Introduction: The slow atrioventricular nodal pathway (SP) typically has a single atrial breakthrough site.

Methods And Results: We report a case of fast-slow type AVNRT with two distinct atrial breakthrough sites during tachycardia. The earliest atrial activation site (EAAS) was at the right inferior septum, followed by the inferolateral wall of the tricuspid annulus.

Atypical atrial resetting with ventricular extrastimulus during tachycardia: What is the mechanism?

This atypical atrial resetting with ventricular extrastimulus delivered during supraventricular tachycardia is characterized by no capture of local ventricular deflection contralateral to the earliest atrial site and is a finding unmasking the presence of a nodoventricular pathway, the ventricular insertion of which is located apically, away from the mitral annulus.

Novel Q234K variant, identified in patients with long QT syndrome and epileptiform activity, induces both gain- and loss-of-function of slowly activating delayed rectifier potassium currents.

Introduction: KCNQ1 and KCNE1 form slowly activating delayed rectifier potassium currents (I). Loss-of-function of I by variants causes type-1 long QT syndrome (LQTS). Also, some variants are reported to cause epilepsy.