Maternal high-fat or low-protein diets promote autism-related behavior and altered social behavior within groups in offspring male mice.

Maternal malnutrition has been associated with neurodevelopmental deficits and long-term implications on the offspring's health and behavior. Here, we investigated the effects of maternal low-protein diet (LPD) or obesity-inducing maternal high-fat diet (HFD) on dyadic social interactions, group organization and autism-related behaviors in mice. We found that maternal HFD induced an autism-related behavioral phenotype in the male offspring, including a robust decrease in sociability, increased aggression, cognitive rigidity and repetitive behaviors.

Sexually dimorphic oxytocin circuits drive intragroup social conflict and aggression in wild house mice.

In nature, both males and females engage in competitive aggressive interactions to resolve social conflicts, yet the behavioral principles guiding such interactions and their underlying neural mechanisms remain poorly understood. Through circuit manipulations in wild mice, we unveil oxytocin-expressing (OT) neurons in the hypothalamic paraventricular nucleus (PVN) as a neural hub governing behavior in dyadic and intragroup social conflicts, influencing the degree of behavioral sexual dimorphism. We demonstrate that OT PVN neurons are essential and sufficient in promoting aggression and dominance hierarchies, predominantly in females.

Sexual behavior and drive: Is it all in your brain?

Male mating behavior involves a series of behaviors aimed to recognize, approach and mate with a female. A new study in mice reveals an elaborated neural circuit that drives both sexual recognition, sexual reward, and copulatory behavior.