Paleomagnetic evidence for Neoarchean plate mobilism.

Plate tectonics is a unique feature of Earth, but its proposed time of initiation is still controversial, with published estimates ranging from ca. 4.2 to 0.

Sodium chloride impacts glycosylation and N- and O-glycan site occupancy of an Fc-fusion protein.

Fc-fusion proteins are highly complex molecules, difficult to manufacture at scale. In this work, undesired proteoforms were detected during the manufacture of a therapeutic fusion protein produced in CHO cells. These species were characterized using gel electrophoresis, size exclusion chromatography and liquid chromatography-mass spectrometry leading to the identification of low molecular weight proteoforms presenting low N- and O-glycan site occupancy, as well as a low sialylation content.

Tebentafusp in Patients with Metastatic Uveal Melanoma: A Real-Life Retrospective Multicenter Study.

Background: Tebentafusp has recently been approved for the treatment of metastatic uveal melanoma (mUM) after proving to have survival benefits in a first-line setting.

Patients And Methods: This retrospective, multicenter study analyzed the outcomes and safety of tebentafusp therapy in 78 patients with mUM.

Results: Patients treated with tebentafusp had a median PFS of 3 months (95% CI 2.

Biological Durability of Wood-Polymer Composites-The Role of Moisture and Aging.

Knowledge about the resistance of wood-polymer composites (WPCs) to biological attack is of high importance for purpose-oriented use in outdoor applications. To gain this knowledge, uniform test methods are essential. EN 15534-1 (2018) provides a general framework, including the recommendation of applying a pre-weathering procedure before the biological laboratory tests.