Publications by authors named "T Kikugawa"
Article Synopsis
- Androgens play a key role in regulating skeletal muscle mass, but the exact mechanism behind muscle loss due to androgen deficiency is not fully understood.
- Research using different mouse models revealed that systemic knockout of androgen receptors leads to reduced muscle strength and mass, while selective knockout affects strength without changing mass, indicating non-myofiber influences.
- The study highlighted epidermal growth factor receptor (EGFR) as a significant protein linked to androgen levels, showing that EGFR contributes to muscle mass regulation and protein synthesis, especially in males.
Background: Robot-assisted surgery is widely performed for renal cell carcinoma (RCC) with inferior vena cava (IVC) tumor thrombi. Although many chemotherapeutic options are available for the treatment of unresectable RCC, there are very few reports on robot-assisted radical nephrectomy (RARN) with inferior vena cava thrombectomy (IVCT) after presurgical treatment with immune checkpoint inhibitors and tyrosine kinase inhibitors. We believe that pre-surgical treatment can provide minimally invasive surgical benefits to high-risk patients during the perioperative period.
View Article and Find Full Text PDFCan Pelvic Lymph Node Dissection in Prostate Cancer Patients with a 5% Briganti Nomogram Cut-off Value Provide an Oncological Benefit? A Large Multi-Institutional Cohort Study in Japan.
Acta Med Okayama
August 2024
Article Synopsis
- The Briganti nomogram, with a 5% cut-off, is used to decide if pelvic lymph node dissection (PLND) is necessary for prostate cancer patients.
- A study analyzed data from 1,068 patients who had radical prostatectomy and found no significant oncological benefit of PLND for those with a Briganti score of 5%.
- High PSA levels and advanced T-stage were linked to worse biochemical recurrence-free survival, while PLND did not have a meaningful impact on recurrence outcomes.
Intraductal carcinoma of the prostate (IDCP) has recently attracted increasing interest owing to its unfavorable prognoses. To effectively identify the IDCP-specific gene expression profile, we took a novel approach of characterizing a typical IDCP case using spatial gene expression analysis. A formalin-fixed, paraffin-embedded sample was subjected to Visium CytAssist Spatial Gene Expression analysis.
View Article and Find Full Text PDFNeuroendocrine prostate carcinoma (NEPC) accounts for less than 1% of prostate neoplasms and has extremely poorer prognosis than the typical androgen receptor pathway-positive adenocarcinoma of the prostate (ARPC). However, very few cases in which de novo NEPC and APRC are diagnosed simultaneously in the same tissue have been reported. We report herein a 78-year-old man of de novo metastatic NEPC coexisting with ARPC treated at Ehime University Hospital.
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