Publications by authors named "T Kievits"
Article Synopsis
- COVID-19 highlighted the urgent need for rapid diagnostic testing, revealing the limitations of traditional RT-qPCR methods, which are complex and time-consuming.
- Loop-mediated isothermal amplification (LAMP) emerged as a faster, more flexible, and cost-effective alternative for detecting SARS-CoV-2 during the pandemic, though there was a need to scale this testing method due to increased demand.
- The TOMi corona initiative developed the SMART-LAMP system, capable of processing 40,000 samples daily with comparable sensitivity to RT-qPCR, while focusing on sustainability and improving pandemic preparedness through automated testing technologies.
Differentiated non-medullary thyroid cancer (NMTC) can be effectively treated by surgery followed by radioactive iodide therapy. However, a small subset of patients shows recurrence due to a loss of iodide transport, a phenotype frequently associated with BRAF V600E mutations. In theory, this should enable the use of existing targeted therapies specifically designed for BRAF V600E mutations.
View Article and Find Full Text PDFMedicine and healthcare are undergoing profound changes. Whole-genome sequencing and high-resolution imaging technologies are key drivers of this rapid and crucial transformation. Technological innovation combined with automation and miniaturization has triggered an explosion in data production that will soon reach exabyte proportions.
View Article and Find Full Text PDFAlthough immunoassays have long served as the standard in the field of diagnostics, the advent of nucleic acid amplification technologies allows for a new array of diagnostic applications. NASBA, nucleic acid sequence-based amplification, is one such technology that is highly suited for the amplification of RNA. As such, NASBA is applied readily as a diagnostic tool for infectious diseases, particularly for RNA viruses, such as retroviruses.
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