Publications by authors named "T Kezuka"
Purpose: To investigate the usage status of biologics for the chronic treatment of optic neuritis including neuromyelitis optica spectrum disorders in Japan.
Design: Multicenter retrospective case series.
Methods: Patients diagnosed with anti-aquaporin 4 antibody (AQP4-Ab) positive optic neuritis and had been initiated on biologics (satralizumab, eculizumab, and inebilizumab) between January 2020 and August 2022 were identified at 30 facilities in Japan.
Article Synopsis
- The study aimed to evaluate how idebenone treatment affects visual function in patients with Leber's Hereditary Optic Neuropathy (LHON) using fMRI, which looks at brain activity related to vision.
- Four LHON patients were treated with oral idebenone for 24 weeks, and their visual functions were assessed using various tests, including fMRI while observing visual stimuli.
- Results showed mixed responses; one patient improved positively, two had stable conditions, and another had discrepancies between visual field improvements and worsening symptoms, indicating the need for further research on fMRI's effectiveness in measuring visual function in LHON.
Although there is a substantial amount of data on the clinical characteristics, diagnostic criteria, and pathogenesis of myelin oligodendrocyte glycoprotein (MOG) autoantibody-associated disease (MOGAD), there is still uncertainty regarding the MOG protein function and the pathogenicity of anti-MOG autoantibodies in this disease. It is important to note that the disease characteristics, immunopathology, and treatment response of MOGAD patients differ from those of anti-aquaporin 4 antibody-positive neuromyelitis optica spectrum disorders (NMOSDs) and multiple sclerosis (MS). The clinical phenotypes of MOGAD are varied and can include acute disseminated encephalomyelitis, transverse myelitis, cerebral cortical encephalitis, brainstem or cerebellar symptoms, and optic neuritis.
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- The study aimed to investigate the radial peripapillary capillaris (RPC) and intra-papillary capillaris (IPC) in patients with acute retinal necrosis (ARN) using optical coherence tomography angiography (OCTA).
- Thirteen patients were analyzed, and while 12 showed no visual abnormalities through standard eye exams, OCTA revealed significant issues: 69% had RPC morphological abnormalities, and 62% showed a decrease in capillary networks.
- The findings indicate that even in cases of ARN that appear mild and have good visual outcomes, there are underlying impairments in the capillaries, suggesting possible optic nerve damage.