Publications by authors named "T Keve"

The Jung-Ferenczi dossier.

Am J Psychoanal

March 2015

The acquaintance between Sándor Ferenczi and C G Jung pre-dates their first encounter with Sigmund Freud. Later, a triangular relationship developed when the three men crossed the Atlantic together and spent an extended period in one another's company. Ferenczi's friendship with Jung could not survive the latter's break with Freud, but its development between 1907 and 1913 is evidenced by unpublished letters from Jung to Ferenczi, found in the Ferenczi Archive, now at the Freud Museum.

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The authors report their preclinical and clinical test results of an infusion (Diabole) made of dill (Anethum graveolens), nettle (Urtica dioica) and gingko (Gingko biloba) herbal mixture and accordingly, this preparation given in right dosages could be suitable for reducing blood sugar level significantly in II. type of diabetes mellitus.

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A new semisynthetic anti-tumour bis-indol compound, KAR-2 [3'-(beta-chloroethyl)-2',4'-dioxo-3,5'-spiro-oxazolidino-4-dea cetoxy-vinblastine] with lower toxicity than vinca alkaloids used in chemotherapy binds to calmodulin but, in contrast to vinblastine, does not exhibit anti-calmodulin activity. To investigate whether the modest chemical modification of bis-indol structure is responsible for the lack of anti-calmodulin potency and for the different pharmacological effects, new derivatives have been synthesized for comparative studies. The synthesis of the KAR derivatives are presented.

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1. KAR-2 (3"-(beta-chloroethyl)-2",4"-dioxo-3,5"-spiro-oxazolidino- 4-deacetoxy-vinblastine), is a bis-indol derivative; catharantine is coupled with the vindoline moiety which contains a substituted oxazolidino group. Our binding studies showed that KAR-2 exhibited high affinity for bovine purified brain tubulin (Kd-3 microM) and it inhibited microtubule assembly at a concentration of 10 nM.

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