HISTOLOGICAL AND IMMUNOHISTOCHEMICAL STUDIES OF ATHEROSCLEROTIC AND SENILE CALCIFIC AORTIC VALVE STENOSIS.

THE GOAL OF THIS STUDY: description of morphogenesis aortic valve stenosis in the senile and vice atherosclerotic aortic valve and definition inflammatory processes in them, improving pathology-anatomic diagnostic, macro- and microscopic examination of the stage of development of atherosclerotic plaques in the operating material fragments of aortic valve on the basis of morphological (histochemical and immunohistochemical studies by using markers CD31, VEGF) and idiopathic characteristics of atherosclerotic plaques, the differential diagnosis of the degree of calcification of the aortic valve in the atherogenic and idiopathic aortic stenosis. Calcification in senile aortic stenosis is characterized by three main parameters: infiltration of inflammatory cells, while senile origin stenosis observed the potential growth of angiogenesis. In endothelial walls of the aortic valve imunnhistochemicaly revealed high expression of endothelial and panendothelial growth factors.