Microneedle patch based on dissolving, detachable microneedle technology for improved skin quality of the periorbital region. Part 2: Clinical Evaluation.

Objective: Microneedle patches based on dissolving, detachable microneedle technology (Russian patent No. 2652567; US patent EFS No. 32735812; WO/2019/231360) are novel dermatological products that allow safe, painless and effective reduction of epidermal wrinkles after six procedures.

Microneedle patch based on dissolving, detachable microneedle technology for improved skin quality - Part 1: ex vivo safety evaluation.

Objective: The aim of the paper presented herein is the description and safety evaluation of the process of dissolution of an 86-microneedle patch composed of hyaluronic acid, when applied topically to human abdominal skin explants. Such explants were chosen to replace the inability of obtaining periorbital skin. In order to evaluate penetration and dissolution of the microneedles, we employed histochemical methods and a fluorescent dye FITC (fluorescein isothiocyanate).

[Biosorption ability of mutants of Rhodotorula mucilaginosa UCM Y-1776].

Twenty stable mutants with various coloration intensity have been allocated in carotene-synthesizing natural strain Rhodotorula mucilaginosa UCM Y-1776 (wild type) after nitrosoguanidine action. Two brightly orange mutants 4L and 11 and one non-pigmented mutant 2 were chosen for the further researches. The ultraviolet was inefficient as a mutagen.

[Intensification of extraction by yeast Saccharamyces cerevisiae 1968 of copper ions from a solution in magnetic field].

It was determined whether it is possible to intensify the biosorption of copper ions from a copper sulfate solution with yeast Saccharomyces cerevisiae 1968 by introducing a metal headpiece into the solution and by applying an external magnetic field. The study was carried out in a magnetic field oriented both parallel and perpendicular to the axes of the rods (with parallel and perpendicular geometry of the system) that make up the headpiece. It was shown that the extent of intensification of the extraction of copper ions at different geometries of the system differs insignificantly and that the extraction of copper ions from the solution occurs by biosorption and cementation onto the metal headpiece.

[Effect of chromium (VI) on growth physiology and sorptional capacity of yeast].

Resistance of 7 yeast species (7 strains) to various chrome concentrations in the medium and their sorptional activity have been studied. It is shown that the biomass of the yeast Williopsis californica UKM-248, Candida krusei UKM-61t under their concentration in the medium of 200 and 500 mg/l of Cr6+ is 0.74 and 0.