Effects of a propofol--ketamine admixture in human volunteers.

As the ideal sedative does not exist for all situations, particularly in settings with limited resources, the effect of a propofol-ketamine combination in human volunteers was examined. Eleven American Society of Anesthesiologists (ASA) physical status I volunteers were administered propofol at a loading dose of 1 mg/kg and two minutes later by 0.7 mg/kg of ketamine.

The effects of epinephrine in local anesthetics on plasma catecholamine and hemodynamic responses.

In order to clarify the influence of epinephrine in local anesthetics on endogenous epinephrine, we examined the concentration of plasma catecholamines (epinephrine and norepinephrine) and hemodynamics by administering 4 ml of 2% lidocaine containing different concentrations of epinephrine. Forty-three healthy adult male volunteers were divided into five groups according to epinephrine concentration: 0-microg (group I), 10-microg (group II), 20-microg (group III), 40-microg (group IV), and 50-microg (group V). The parameters were examined immediately, and at 1, 2, 3, 4, 5, 10, 15, and 20 min after the injection.

Sedation in Japanese dental schools.

There is very little information about the practice of sedation in Japan. Despite the remarkable advances in dentistry, fear and anxiety continue to be significant deterrents for seeking dental services. Most dental procedures can fortunately be undertaken with the aid of sedation.

Effects of a midazolam-ketamine admixture in human volunteers.

As the ideal sedative does not exist for all situations, we examined the effect of a midazolam-ketamine sedoanalgesic admixture in human volunteers. Ten ASA physical status I volunteers were administered loading doses of 0.07 mg/kg of midazolam followed by 0.

Decreased intraoral secretions during sedation-analgesia with propofol-ketamine and midazolam-ketamine combinations.

Purpose: To investigate salivary flow over time with a balanced sedation-analgesia technique using a propofol-ketamine (PK) or a midazolam-ketamine (MK) combination in human volunteers.

Methods: In the PK group, boluses of 1 mg.kg(-1) of propofol and 0.