Publications by authors named "T Kangas"

Article Synopsis
  • - T cell-mediated destruction of insulin-producing islets is a key feature of autoimmune diabetes, and this study focused on the behavior of CD4 T cells reacting to insulin-derived peptides in NOD mice during diabetes onset.
  • - Using single-cell RNA sequencing, researchers found that T cells specific to islet antigens varied greatly in their development and needed XCR1 dendritic cells for activation, with varying effector profiles among different epitope-specific T cells.
  • - Notably, CD4 T cells responsive to hybrid-insulin C-chromogranin A were found to be pathogenic, and targeting these cells with specific antibodies prevented diabetes, suggesting potential for targeted therapies in treating autoimmune diabetes.
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Removal of dissolved zinc (Zn) from water by a novel alkali-activated material (AAM) prepared from steel industry slags in a fixed-bed column was investigated. Design of experiments was used to find the optimum operation parameters [flow rate , adsorbent mass, (), and initial Zn concentration ()] for the removal of Zn from a ZnCl solution. Regression models for the breakthrough (), and saturation () capacities of the bed and three other response parameters as functions of , and were fitted with coefficients of determination () ranging from 0.

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Background: There is ample evidence that air pollution increases mortality risk, but most studies are based on modelled estimates of air pollution, while the subjective perception of air quality is scarcely assessed. We aimed to compare the effects of objective and subjective exposure to air pollution on cardiorespiratory mortality in Brussels, Belgium.

Methods: Data consisted of the 2001 Belgian census linked to registry-based mortality data for the follow-up period 2001-2014.

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Naturally occurring layered double hydroxide mineral, brucite (BRU), was compared with hydromagnesite (HYD) and a commercial Mg-rich mineral adsorbent (trade name AQM PalPower M10) to remove antimony (Sb) from synthetic and real wastewaters. The BRU and HYD samples were calcined prior to the experiments. The adsorbents were characterized using X-ray diffraction, X-ray fluorescence, and Fourier transform infrared spectroscopy.

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Imprime PGG (Imprime) is in late-stage clinical development as a combinatorial agent with several therapeutic modalities. Here we present pre-clinical mechanistic data supportive of Imprime, a soluble yeast β-1,3/1,6-glucan pathogen-associated molecular pattern able to prime innate immune cells in a Dectin-1dependent manner. In tumor-free mice, Imprime evoked broad innate immune responses (type I interferon signature, mobilization of myeloid cells, dendritic cell and monocyte/macrophage expression of co-stimulatory ligands like CD86, and activation of natural killer cells).

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