Publications by authors named "T Kamijima"
We investigated the mechanisms of interaction between bladder cancer (BC) cells and tumor-associated macrophages (TAMs). Coculturing BC cell lines (UMUC3 and T24) with macrophage-like cells differentiated from THP-1 into M2-like TAMs revealed a decrease in Cluster of Differentiation (CD) 68 expression and an increase in CD206 expression. This differentiation enhanced BC cell migration and invasion.
View Article and Find Full Text PDFArticle Synopsis
- Enfortumab vedotin (EV) is used to treat metastatic urothelial carcinoma (mUC), but the study aimed to compare the safety and efficacy of standard versus biweekly administration.
- The research included two patient groups: one receiving standard EV treatment and the other receiving it biweekly, and it evaluated their treatment outcomes and side effects (AEs).
- Results showed no significant differences in survival rates or response between the groups, but the biweekly group experienced fewer side effects, suggesting it may be a safer option.
Article Synopsis
- Intraoperative hypotension is a significant issue during photodynamic diagnosis-assisted transurethral resection of bladder tumors, particularly when using oral 5-aminolevulinic acid, prompting a re-evaluation of its safety.
- A study involving 407 cases highlighted that patients in the photodynamic diagnosis (PDD) group experienced more moderate to severe hypotension compared to the white light (WL) group, with renal function declining as hypotension severity increased.
- Findings suggest that anesthesia type may influence hypotension severity, with general anesthesia linked to milder cases and spinal anesthesia associated with severe cases, indicating a need for further research to understand specific risk factors better.
Bone is a common site of prostate cancer metastasis. Bone turnover markers n-terminal propeptide of type I procollagen (P1NP) and tartrate-resistant acid phosphatase type 5b (TRACP-5b) are highly sensitive to bone remodeling activity. However, their prognostic significance as markers of prostate cancer is unknown.
View Article and Find Full Text PDFObjectives: Patients with advanced cancer may develop bacterial infections (BI) as their general condition worsens, but general blood tests often find it difficult to distinguish them from non-bacterial infections (NBI). The present prospective study was undertaken to investigate the effectiveness of serum procalcitonin levels in distinguishing between BI and NBI in patients with advanced urological cancer.
Methods: This study prospectively evaluated patients diagnosed with locally advanced or metastatic or recurrent urological cancer in our department from September 2013 to December 2019.