Publications by authors named "T Kamigaki"
Personalized Dendritic-cell-based Vaccines Targeting Cancer Neoantigens.
Anticancer Res
September 2024
Cancer immunotherapy activates the host immune system against tumor cells and has the potential to lead to the development of innovative strategies for cancer treatment. Neoantigens are non-self-antigens produced by genetic mutations in tumor cells that induce a strong immune response against tumor cells without central immune tolerance. Along with advances in neoantigen analysis technology, the development of vaccines focusing on neoantigens is being accelerated.
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- A study in Japan examined pediatric patients aged 0-19 who died from SARS-CoV-2 infection between January and September 2022, identifying 62 cases and analyzing detailed medical information from 53 of those patients.
- Of the patients with internal causes of death, 15% were infants under 1 year old, 59% had no underlying health conditions, and 88% of those eligible for vaccination had not been vaccinated.
- Key findings showed that 46% experienced out-of-hospital cardiac arrest, nonrespiratory symptoms were more prevalent than respiratory symptoms, and the primary suspected causes of death were central nervous system and cardiac abnormalities; the study emphasizes close monitoring of pediatric patients in the week following symptom onset
Article Synopsis
- The study examines how the COVID-19 pandemic affected the occurrence of certain respiratory bacteria, highlighting significant changes in their epidemiology due to new social behaviors and non-pharmaceutical interventions (NPIs).
- Researchers analyzed data from a national surveillance database from 2018 to 2021, comparing cases of four bacteria before and after the pandemic, focusing on different age groups and specimen sources.
- Findings showed a significant drop in cases of S. pneumoniae, H. influenzae, and S. pyogenes between 2019 and 2020, with a resurgence in 2021, particularly among young children, indicating the varied impact of NPIs on different bacteria and demographics.