Publications by authors named "T Kaisho"
Lysosomal stress due to the accumulation of nucleic acids (NAs) activates endosomal TLRs in macrophages. Here, we show that lysosomal RNA stress, caused by the lack of RNase T2, induces macrophage accumulation in multiple organs such as the spleen and liver through TLR13 activation by microbiota-derived ribosomal RNAs. TLR13 triggered emergency myelopoiesis, increasing the number of myeloid progenitors in the bone marrow and spleen.
View Article and Find Full Text PDFPurpose: Type I conventional dendritic cells (cDC1s) play a key role in priming anti-tumor cytotoxic T cells and inducing immune tolerance for self-antigens and tumor antigens. However, it remains unclear whether cDC1 has a protective or pathogenic role in multiple myeloma. We investigated a role of cDC1 in myeloma progression.
View Article and Find Full Text PDFThe oral mucosa is the first line of defense against pathogenic bacteria and plays a vital role in maintaining tolerance to food antigens and commensal bacteria. We used CD11c reporter mice to visualize dendritic cells (DCs), a key immune cell population, in the oral cavity. We identified differences in DC density in each oral tissue region.
View Article and Find Full Text PDFArticle Synopsis
- * Early intermittent feeding of mice on a high-cholesterol diet speeds up atherosclerosis by altering arterial macrophage behavior and gene expression associated with ASCVD.
- * The Young Finns Study links early cholesterol exposure to increased carotid atherosclerotic plaque in adulthood, emphasizing the need for better hyperlipidaemia management early in life to prevent ASCVD.
Article Synopsis
- - T cell-mediated destruction of insulin-producing islets is a key feature of autoimmune diabetes, and this study focused on the behavior of CD4 T cells reacting to insulin-derived peptides in NOD mice during diabetes onset.
- - Using single-cell RNA sequencing, researchers found that T cells specific to islet antigens varied greatly in their development and needed XCR1 dendritic cells for activation, with varying effector profiles among different epitope-specific T cells.
- - Notably, CD4 T cells responsive to hybrid-insulin C-chromogranin A were found to be pathogenic, and targeting these cells with specific antibodies prevented diabetes, suggesting potential for targeted therapies in treating autoimmune diabetes.