Publications by authors named "T Kado"
Objectives: In this study, we compared the performance of ChatGPT-3.5 to that of ChatGPT-4o in the context of the Japanese National Dental Examination, which assesses clinical reasoning skills and dental knowledge, to determine their potential usefulness in dental education.
Methods: ChatGPT's performance was assessed using 1399 (55% of the exam) of 2520 questions from the Japanese National Dental Examinations (111-117).
Unlabelled: Disruption of the gut microbiota causes metabolic dysfunction, and intervention in the gut microbiota has the potential to improve host glucose metabolism. is an intestinal bacterium involved in anti-obesity and insulin resistance. Developing interventions to increase would be useful for new treatment strategies.
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- Islet transplantation (ITx) is a promising treatment for type 1 diabetes (T1DM), but many recipients lose insulin independence within three years due to early graft loss, necessitating multiple donor organs.
- The study found that skeletal myoblast cells can support islet function by promoting angiogenesis (formation of new blood vessels) and helping maintain the islet cells' ability to secrete insulin through cytokine release and JAK-STAT signaling activation.
- In tests on diabetic mice, islets transplanted with myoblast cells resulted in lower blood glucose levels and increased insulin production compared to islets alone, suggesting that using myoblast cells in ITx could improve outcomes for diabetes patients.
Background: Chronic pancreatitis (CP) is a progressive disease characterized by pancreatic fibrosis for which effective treatment options are lacking. Mesenchymal stem cells (MSCs) have shown potential for fibrosis treatment but face limitations in clinical application. The high-mobility group box 1 (HMGB1) fragment mobilizes MSCs from bone marrow into the blood and has emerged as a promising therapeutic agent for tissue regeneration in various pathological conditions.
View Article and Find Full Text PDFMacrophages contribute to adipose tissue homeostasis; however, they are also thought to be responsible for insulin resistance in obesity. Macrophages, which were oversimplified in past methodologies, have become rather difficult to understand comprehensively as recent developments in research methodology have revealed their diversity. This review highlights recent studies on adipose tissue macrophages, identifies controversial issues that need to be resolved and proposes a scenario for further development of adipose tissue macrophage biology.
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