Publications by authors named "T K Tryggvason"
A 68-year-old patient came to the emergency department complaining of headaches and general weakness for the past month. The patient is known to have myeloproliferative disease. Non-contrast computer tomography showed a hyperdense extra-axial collection in bilateral frontoparietal regions, which was presumed to be bilateral subdural hematoma as the initial diagnosis.
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- Undifferentiated pleomorphic sarcoma (UPS) is a rare but aggressive type of soft-tissue sarcoma, previously called malignant fibrous histiocytoma (MFH), that often spreads to distant sites.
- A case is reported involving a 49-year-old woman with high-grade UPS in the colon, a very rare location for this kind of cancer.
- This case highlights the need to consider UPS when diagnosing colonic tumors and emphasizes the importance of recognizing its clinical and pathological features for effective treatment.
HER-3 (also known as ErbB-3) is a human epidermal growth factor receptor tyrosine kinases family member, and its expression in CRC (colorectal cancer) tissues was previously associated with poor prognosis. In this study, HER-3 expression was analyzed by immunohistochemistry in two cohorts of early and advanced metastatic CRC patients. The first cohort included 180 patients diagnosed with CRC in absence of lymph nodes or distant metastases (Stage I and Stage II), while the second was obtained from 53 advanced metastatic CRC patients who developed synchronous (SM) and metachronous (MM) liver metastases.
View Article and Find Full Text PDFBackground: The TNM system is used to assess prognosis after colorectal cancer (CRC) diagnosis. Other prognostic factors reported include histopathological assessments of the tumour, tumour mutations and proteins in the blood. As some of these factors are strongly correlated, it is important to evaluate the independent effects they may have on survival.
View Article and Find Full Text PDFPurpose: Universal screening for Lynch syndrome (LS) on resected colorectal carcinomas (CRCs) and endometrial carcinomas (ECs) was implemented in Iceland in 2017 using immunohistochemistry (IHC) for mismatch repair (MMR) proteins. We examined the efficacy of the universal screening algorithm to detect LS and the diagnostic accuracy of MMR IHC by comparing results with a population-based genotype database.
Methods: All patients diagnosed with CRC or EC per the Icelandic Cancer Registry from 2017 to 2019 who had tumor MMR IHC performed were included.