Publications by authors named "T K Tedesco"
The progressive accumulation of amyloid beta (Aβ) pathology in the brain has been associated with aberrant neuronal network activity and poor cognitive performance in preclinical mouse models of Alzheimer's disease (AD). Presently, our understanding of the mechanisms driving pathology-associated neuronal dysfunction and impaired information processing in the brain remains incomplete. Here, we assessed the impact of advanced Aβ pathology on spatial information processing in the medial entorhinal cortex (MEC) of 18-month knock-in (APP KI) mice as they explored contextually novel and familiar open field arenas in a two-day, four-session recording paradigm.
View Article and Find Full Text PDFIntroduction: Selective outcome reporting (SOR) is a bias that can occur in randomized controlled trials (RCTs), defined as the alteration or omission of primary outcome in the publication compared to the original protocol. Researchers may modify outcomes to highlight statistically significant results. This study aimed to assess the prevalence of SOR in RCTs related to dental caries in children and adolescents.
View Article and Find Full Text PDFArticle Synopsis
- Systematic reviews (SRs) are important for making informed decisions, but biases in primary studies can affect their conclusions.
- This study mapped the evidence on managing caries lesions in primary teeth, analyzing 162 SRs with various focuses on treatments.
- The findings revealed low compliance with study registration protocols and showed that most SRs using the GRADE approach rated the certainty of evidence as very low to moderate.
Objectives: The overall pooled success rate of the Hall Technique (HT) in various types of studies has not been investigated. The present study aims to evaluate the success rate of HT to restore carious primary molars.
Methods: A systematic search was carried out in the MEDLINE/PubMed, Excerpta Medica Database (EMBASE), Scopus, Web of Science, and LIVIVO electronic databases, as well as the ProQuest database for grey literature review.
Background: In dental extractions, particularly when local anesthesia is used, it usually offers analgesic relief for a few hours. However, pain can become a notable concern in the immediate postoperative period due to the trauma experienced by both soft and hard oral tissues.
Objectives: This systematic review aimed to evaluate the most effective strategies for managing postoperative pain in primary tooth extractions.