Publications by authors named "T K Stezhka"

Interview with Professor Chris Packard, MD, PhD by Tanya Stezhka (Commissioning Editor) The IMPROVE-IT trial, launched 9 years ago, has finally provided physicians with long-term efficacy and safety evidence for ezetimibe. The large-scale study in acute-coronary-syndrome patients showed a clear benefit in reducing cardiovascular events when added to simvastatin in this population. The size of the benefit was proportionate to the reduction in LDL cholesterol.

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Adipose tissue becomes hypoxic in obesity, and cell culture studies have demonstrated that hypoxia leads to major changes in adipocyte function. Studies on the response of adipocytes to low O₂ tension have employed marked hypoxia (1% O₂). Here, we have examined the effects of modest hypoxia, utilising differing concentrations of O₂ (1-21%), on adipokine production and glucose uptake by human adipocytes.

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