Expression of Elongase- and Desaturase-Encoding Genes Shapes the Cuticular Hydrocarbon Profiles of Honey Bees.

Most terrestrial insects have a layer of cuticular hydrocarbons (CHCs) protecting them from desiccation and mediating chemical communication. The composition of these hydrocarbons is highly plastic and changes during their lifetime and with environmental conditions. How these changes in CHC composition are achieved is largely unknown.

The future of precision oncology and artificial intelligence in Belgium: scenarios and policy responses.

Purpose: Precision medicine, also known as personalized medicine, enables the provision of tailored health services to patients. In the prevention, early detection, and treatment of cancers, precision medicine is highly promising, given the increasing use of genomic profiling for diagnosis and adapting therapies in several tumor types. Artificial Intelligence (AI) can support this process by analyzing vast amounts of relevant data.

Challenges and opportunities for a new era of neuropsychology training: a trainee survey study.

Introduction: The field of neuropsychology is undergoing notable changes, especially in the context of the Minnesota Update Conference (MNC) guidelines draft development. In late 2023, a group of neuropsychology trainee-leaders, united through the Clinical Neuropsychology Trainee Forum (CNTF), surveyed neuropsychology trainees in the United States and Canada to better understand their needs and their perception of the current training climate.

Method: Survey items were drafted by a CNTF task force consisting of trainee-leaders from major neuropsychology organizations before being refined by four independent neuropsychologists.

Room Temperature Dehydrogenation of Gaseous Methanol over Polycrystalline Gold Triggered and Traced by Oxygen K-edge X-rays.

The room temperature conversion of gaseous methanol to carbon monoxide and hydrogen on a polycrystalline Au film at ambient pressure has been triggered and characterized by oxygen K-edge excitation and vibrationally resolved resonant inelastic X-ray scattering. The rate-limiting first methanol dehydrogenation step is driven by ultrafast O-H dissociation and deprotonation of O K-edge excited CHOH. The Au surface further dehydrogenates the CHO photoradical created by X-rays via electron transfer from the Au surface.

The impact of signaling pathways on the desmosome ultrastructure in pemphigus.

Introduction: The autoantibody-driven disease pemphigus vulgaris (PV) impairs desmosome adhesion in the epidermis. In desmosomes, the pemphigus autoantigens desmoglein 1 (Dsg1) and Dsg3 link adjacent cells. Dsgs are clustered by plaque proteins and linked to the keratin cytoskeleton by desmoplakin (Dp).