Publications by authors named "T K Pande"
Structured RNA lies at the heart of many central biological processes, from gene expression to catalysis. RNA structure prediction is not yet possible due to a lack of high-quality reference data associated with organismal phenotypes that could inform RNA function. We present GARNET (Gtdb Acquired RNa with Environmental Temperatures), a new database for RNA structural and functional analysis anchored to the Genome Taxonomy Database (GTDB).
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- Structured RNA is crucial for biological processes, but predicting its structure is challenging due to limited high-quality reference data and lack of associated organismal phenotypes.
- The GARNET database connects RNA sequences from the Genome Taxonomy Database to the optimal growth temperatures of organisms, facilitating the creation of RNA sequence alignments for machine learning.
- The study introduces a GPT-like RNA language model that helps identify mutations in ribosomal RNA that enhance thermostability, laying the groundwork for better understanding RNA sequence, structure, and function relationships.
Artificial Intelligence (AI) based chest X-ray (CXR) screening for tuberculosis (TB) is becoming increasingly popular. Still, deploying such AI tools can be challenging due to multiple real-life barriers like software installation, workflow integration, network connectivity constraints, limited human resources available to interpret findings, etc. To understand these challenges, PATH implemented a TB REACH active case-finding program in a resource-limited setting of Nagpur in India, where an AI software device (qXR) intended for TB screening using CXR images was used.
View Article and Find Full Text PDFIntroduction: It is unclear if serum procalcitonin (PCT) estimated at sepsis suspicion can help detect culture-positive sepsis in neonates. We evaluated the diagnostic performance of PCT in culture-positive sepsis in neonates.
Methods: This was a prospective study (February 2016 to September 2020) conducted in four level-3 units in India.