Publications by authors named "T K Nayak"
Background: The Randomized Evaluation of Decision Support Interventions for Atrial Fibrillation (RED-AF) trial is a multi-site, randomized controlled clinical trial examining the effectiveness of a patient decision aid and an encounter decision aid in promoting shared decision-making (SDM) during a clinical encounter for patients with atrial fibrillation (AF). We sought to describe baseline characteristics of patients and clinicians in the trial and compare them to the demographics of the larger AF population. We also conducted an analysis of possible predictors of attrition rates at baseline, 6 and 12 months.
View Article and Find Full Text PDFOnset timing of letter processing in auditory and visual sensory cortices.
Front Integr Neurosci
November 2024
Here, we report onset latencies for multisensory processing of letters in the primary auditory and visual sensory cortices. Healthy adults were presented with 300-ms visual and/or auditory letters (uppercase Roman alphabet and the corresponding auditory letter names in English). Magnetoencephalography (MEG) evoked response generators were extracted from the auditory and visual sensory cortices for both within-modality and cross-sensory activations; these locations were mainly consistent with functional magnetic resonance imaging (fMRI) results in the same subjects.
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- The study investigates the effectiveness of buprenorphine (BTP) and ketoprofen (KTP) transdermal patches for managing post-operative pain specifically after total knee replacement surgeries, using 100 patients divided into two treatment groups.
- Results show that the BTP group experienced significantly lower pain scores at rest on days 2 to 5 post-surgery, indicating better pain management, while the KTP group required more rescue pain relief.
- Overall, buprenorphine patches appear to provide superior pain relief and higher patient satisfaction without significant side effects compared to ketoprofen in the early post-operative period.
Article Synopsis
- Right heart remodeling is commonly observed in patients suffering from severe COVID-19-related acute respiratory distress syndrome (ARDS), but there is limited information on the recovery of the right heart following lung transplantation for these patients.
- A study at Northwestern University analyzed data from 36 patients who underwent lung transplantation for COVID-19-related ARDS between June 2020 and June 2022, finding that none of the patients died within 90 days, and the 1-year survival rate was 88.8%.
- Postoperative evaluations revealed significant improvements in right ventricle (RV) size and function, as well as reduced pulmonary artery pressure, indicating that right heart recovery can occur relatively quickly after lung transplantation in this specific patient population.
Article Synopsis
- Modern medicine aims to enhance treatment effectiveness while minimizing side effects, with nanoparticles (NPs) offering promising potential for targeted drug delivery and imaging.
- However, the small size of NPs often leads to quick removal from the bloodstream and limited effectiveness due to challenges in crossing important cell barriers.
- This research demonstrates a method to exploit endothelial caveolae in the lungs to improve NP delivery, achieving higher lung concentrations than in the bloodstream, which could enhance both diagnostics and therapies in future medical applications.