Publications by authors named "T K Koo"
The aim of this work was to prepare and characterize gastroretentive floating combination tablets (GRCTs) containing 500 mg of amoxicillin trihydrate (AMX) and 125 mg of levofloxacin (LVX) that provide sustained drug release and stability at gastric pH levels for the eradication of resistant . GRCTs were prepared with low-density excipients and hydrophilic swellable polymers, including hydroxypropyl methylcellulose (HPMC) of various viscosities, polyethylene oxide (PEO), and carboxymethylcellulose (CMC), by the direct compression method. The prepared GRCTs were investigated and optimized in terms of pH stability, tablet hardness, floating lag time and total floating time, drug release rate, gel strength.
View Article and Find Full Text PDFThe clinical application of collagen-based biomaterials is expanding rapidly, especially in tissue engineering and cosmetics. While oral supplements and injectable skin boosters are popular for enhancing skin health, clinical evidence supporting their effectiveness remains limited. Injectable products show potential in revitalizing skin, but safety concerns persist due to challenges in sterilization and the risk of biological contamination.
View Article and Find Full Text PDFThis systematic review explores the complex relationship between artificial intelligence (AI) and healthcare, with an explicit focus on nursing care. Examining a range of studies from 2020, the research investigates the impact of AI on clinical decision-making, patient care and healthcare administration. Through a comprehensive literature review, the study highlights the potential benefits of AI integration in improving the efficiency and efficacy of healthcare.
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- This study investigated the health impacts of heavy metals and volatile organic compounds (VOCs) in fine particulate matter around the Sinpyeong-Jangrim Industrial Complex in Busan.
- Concentrations of harmful substances were measured in five densely populated areas, revealing that carcinogens like benzene and arsenic pose significant health risks to residents.
- The findings underscore the urgent need for pollution reduction strategies and improved air quality management to safeguard community health.
Article Synopsis
- A study called the KROG 1701 trial was conducted to compare the disease-free survival rates of patients with pN1 breast cancer receiving whole-breast irradiation (WBI) alone versus WBI combined with regional node irradiation (RNI) after chemotherapy.
- The trial involved 840 patients, assessing their quality of life through surveys at various stages of treatment, showing improvements in wellbeing across all participants over time.
- While the group receiving WBI+RNI reported slightly more fatigue and nausea during treatment, no significant difference in overall patient experience was found between the two treatment approaches, suggesting both are similarly safe and tolerable.